Enabling tradeoffs in privacy and utility in genomic data Beacons and summary statistics.

The collection and sharing of genomic data are becoming increasingly commonplace in research, clinical, and direct-to-consumer settings. The computational protocols typically adopted to protect individual privacy include sharing summary statistics, such as allele frequencies, or limiting query responses to the presence/absence of alleles of interest using web services called Beacons. However, even such limited releases are susceptible to likelihood ratio-based membership-inference attacks. Several approaches have been proposed to preserve privacy, which either suppress a subset of genomic variants or modify query responses for specific variants (e.g., adding noise, as in differential privacy). However, many of these approaches result in a significant utility loss, either suppressing many variants or adding a substantial amount of noise. In this paper, we introduce optimization-based approaches to explicitly trade off the utility of summary data or Beacon responses and privacy with respect to membership-inference attacks based on likelihood ratios, combining variant suppression and modification. We consider two attack models. In the first, an attacker applies a likelihood ratio test to make membership-inference claims. In the second model, an attacker uses a threshold that accounts for the effect of the data release on the separation in scores between individuals in the data set and those who are not. We further introduce highly scalable approaches for approximately solving the privacy-utility tradeoff problem when information is in the form of either summary statistics or presence/absence queries. Finally, we show that the proposed approaches outperform the state of the art in both utility and privacy through an extensive evaluation with public data sets.

Re-identification of individuals in genomic datasets using public face images.

Recent studies suggest that genomic data can be matched to images of human faces, raising the concern that genomic data can be re-identified with relative ease. However, such investigations assume access to well-curated images, which are rarely available in practice and challenging to derive from photos not generated in a controlled laboratory setting. In this study, we reconsider re-identification risk and find that, for most individuals, the actual risk posed by linkage attacks to typical face images is substantially smaller than claimed in prior investigations. Moreover, we show that only a small amount of well-calibrated noise, imperceptible to humans, can be added to images to markedly reduce such risk. The results of this investigation create an opportunity to create image filters that enable individuals to have better control over re-identification risk based on linkage.